WZ4003
- Product Name
- WZ4003
- CAS No.
- 1214265-58-3
- Chemical Name
- WZ4003
- Synonyms
- WZ4003;CS-1174;WZ 4003;WZ4003;N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]propanamide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide;N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide;Propanamide, N-[3-[[5-chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-
- CBNumber
- CB92707353
- Molecular Formula
- C25H29ClN6O3
- Formula Weight
- 496.99
- MOL File
- 1214265-58-3.mol
WZ4003 Property
- Density
- 1.303±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- insoluble in H2O; ≥2.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥7.85 mg/mL in DMSO with gentle warming
- form
- powder
- pka
- 14.27±0.70(Predicted)
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML1445
- Product name
- WZ4003
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $89.6
- Updated
- 2023/06/20
- Product number
- SML1445
- Product name
- WZ4003
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $451
- Updated
- 2023/06/20
- Product number
- 19177
- Product name
- WZ4003
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19177
- Product name
- WZ4003
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 19177
- Product name
- WZ4003
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
WZ4003 Chemical Properties,Usage,Production
Uses
WZ4003 is a highly specific protein kinase inhibitor of NUAK kinases.
Biological Activity
wz4003 is a potent and selective inhibitor of nuak1 and nuak2 with ic50 values of 20 and 100 nm, respectively [1].nuak family snf1-like kinase-1 (nuak1) and the related nuak2 belong to the amp-activated protein kinase (ampk) family and are activated by liver kinase b1 (lkb1) tumour suppressor protein kinase [1].wz4003 is a potent and selective nuak1/2 inhibitor. in hek-293 cells, wz4003 inhibited the phosphorylation of myosin phosphate-targeting subunit 1 (mypt1), which was phosphorylated by nuak1 at ser445. in hek-293 cells overexpressing inhibitor-resistant nuak1[a195t], wz4003 didn’t inhibit the phosphorylation of mypt1 at ser445. in mouse embryonic fibroblasts (mefs), wz4003 significantly inhibited migration in a wound-healing assay and inhibited mefs proliferation. in a cell invasion assay, wz4003 inhibited the invasive potential of u2os cells [1]. in u2os cells, wz4003 (10 μm) inhibited phosphorylation of mypt1 and reduced the cells in s-phase by 50%. also, wz4003 prevented cells from entering into mitosis [2].
Biochem/physiol Actions
WZ4003 helps to repress the migration of cells. It also prevents cell proliferation.
storage
Store at -20°C
References
[1]. banerjee s, buhrlage sj, huang ht, et al. characterization of wz4003 and hth-01-015 as selective inhibitors of the lkb1-tumour-suppressor-activated nuak kinases. biochem j, 2014, 457(1): 215-225.
[2]. banerjee s, zagórska a, deak m, et al. interplay between polo kinase, lkb1-activated nuak1 kinase, pp1βmypt1 phosphatase complex and the scfβtrcp e3 ubiquitin ligase. biochem j, 2014, 461(2): 233-245.
WZ4003 Preparation Products And Raw materials
Raw materials
Preparation Products
WZ4003 Suppliers
View Lastest Price from WZ4003 manufacturers
- Product
- WZ4003 1214265-58-3
- Price
- US $0.10/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 1g,10g,1kg
- Release date
- 2020-01-10